We think of cancer as caused by mutations. Mutations are necessary, but not sufficient, to cause cancer. New research indicates that it’s the body’s response to mutant cells that determines whether cancer will develop. James S. Welsh, MD, a radiation oncologist and researcher, has written a book on the immunology… read more "Sharks Get Cancer, Mole Rats Don’t: Clues to Understanding Cancer"
The Essential Role of Regulation In Human Health and In Ecology: The Serengeti Rules
The doubling time for E.coli bacteria is 20 minutes. With uncontrolled growth, it would take a mere two days for the weight of bacteria to equal the weight of the Earth. What rules determine the actual numbers of bacteria? Why is the world green; why don’t insects eat all the leaves? How… read more "The Essential Role of Regulation In Human Health and In Ecology: The Serengeti Rules"
Immunity: More Than Just Antibodies and Vaccines
Since I graduated from medical school, new scientific developments in immunology have been occurring at a prodigious rate. I knew I could use a refresher course, and serendipity dropped one in my mailbox in the form of a review copy of the new book Immunity, by William E. Paul, MD, chief of… read more "Immunity: More Than Just Antibodies and Vaccines"
ASEA, ORMUS, and Alchemy
I got an e-mail from a woman who had read my article on ASEA, a multilevel marketing diet supplement that I characterized as an expensive way to buy water. She had not tried ASEA products but was applying for a position as an accountant with the company, and she chastised me… read more "ASEA, ORMUS, and Alchemy"
Aging and Longevity: Science for Spring Chickens
We’re all going to die, but we don’t like to think about it. I’ll reach the proverbial threescore years and ten next month, so I’ve been thinking more about it, wishing I knew some reliable way to ensure that I would live many more years and remain fully functional until… read more "Aging and Longevity: Science for Spring Chickens"
Precision Medicine: The Coolest Part of Medicine
One size rarely fits all. Most medical knowledge is derived from studying groups of subjects, subjects who may be different in some way from the individual who walks into the doctor’s office. Basing medicine only on randomized controlled studies can lead to over-simplified “cookbook” medicine. A good clinician interprets study… read more "Precision Medicine: The Coolest Part of Medicine"
A Skeptic’s Guide to the Mind
In his first book, On Being Certain: Believing You Are Right Even When You’re Wrong,neurologist Robert Burton showed that our certainty that we are right has nothing to do with how right we are. He explained how brain mechanisms can make us feel even more confident about false beliefs than about… read more "A Skeptic’s Guide to the Mind"
Doves, Diplomats, and Diabetes
In the past I have criticized evolutionary medicine for its tendency to rely on unverifiable “Just-So Stories,” but a new book has helped me appreciate what the best kind of evolutionary thinking can contribute to our understanding of medicine. Doves, Diplomats, and Diabetes: A Darwinian Interpretation of Type 2 Diabetes and Related… read more "Doves, Diplomats, and Diabetes"
Adventures on the Alimentary Canal
I write about a lot of depressing subjects, and sometimes a change of pace is welcome. Mary Roach, billed as “America’s funniest science writer,” has followed up on her earlier explorations of cadavers (Stiff), sex (Bonk), the afterlife (Spook), and survival on spaceships (Packing for Mars) with a new… read more "Adventures on the Alimentary Canal"
Thumbthing Worth Reading
I intended to read Sam Kean’s new book The Violinist’s Thumb: And Other Lost Tales of Love, War, and Genius as Written by our Genetic Code just for fun. I was expecting a miscellany of trivia loosely gathered around the theme of DNA. But I found something much more worthwhile that I… read more "Thumbthing Worth Reading"